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Literature summary for 2.7.12.1 extracted from
- Leishmania dual-specificity tyrosine-regulated kinase 1 (DYRK1) is required for sustaining Leishmania stationary phase phenotype (2020), Mol. Microbiol., 113, 983-1002 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| flagellum | GFP-DYRK1 occupies a portion of the flagellar pocket area | Leishmania infantum | - |
- |
| additional information | in logarithmic cultures, GFP-DYRK1 is mainly localized at the anterior side of the cell, outside the flagellar pocket at the anterior end of the kinetoplast and between the nucleus and kinetoplast | Leishmania infantum | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania infantum | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DYRK1 | - |
Leishmania infantum |
| LINF_150006700 | - |
Leishmania infantum |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | DYRK1 overexpressing parasites display a decrease in proliferation and in cell cycle re-entry of arrested cells. Parasites lacking DYRK1 display distinct fitness phenotypes in logarithmic and stationary growth phases. In logarithmic growth phase, DYRK1-/- parasites proliferate better than control lines, while in stationary growth phase, DYRK1-/- parasites round up, accumulate vacuoles and lipid bodies and display subtle but consistent differences in lipid composition. They express less metacyclic-enriched transcripts, display increased sensitivity to complement lysis and a significant reduction in survival within peritoneal macrophages | Leishmania infantum |
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Release 2023.1 (January 2023)
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